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White Mulberry Benefits, Nutrition, And Its Side Effects

White mulberry benefits have a lot. White mulberry is often tried to help treat diabetes. It is also tried for treating high cholesterol levels, high blood pressure, the common cold and its symptoms, muscle and joint pain such as arthritis, constipation, dizziness, ringing in the ears, hair loss, and premature graying. Here we are going to discuss the benefits of white mulberry.

White Mulberry Benefits

White Mulberry Helps Immunity Boost

White mulberry fruits have compounds that increase the activity of macrophages and enhance the immune response. In cells, their extract stimulated the activity of some pro-inflammatory cytokines (TNF-α, IL-1β, IL-6, and IL-10) and messengers (NO and PGE2).

White Mulberry Decrease Anxiety

White mulberry extract increased GABA and reduced dopamine in mice, thus reducing stress-induced behaviors and producing anti-anxiety effects.

White Mulberry Decrease Depression

Sanggenon G, an active compound of white mulberry root bark, had antidepressant effects in rats. Treatment with this compound reduced HPA axis activity and depressive behaviors. White mulberry leaf tea also reduced depressive behavior in mice. However, it also decreased muscle strength and coordination.

White Mulberry Decrease Stress Response

White mulberry may help the body deal with stress by normalizing cortisol levels. Mice exposed to chronic stress for 21 days showed fewer impairments in brain function, mood, hormonal balance, and blood sugar balance when treated with white mulberry root extract.

White Mulberry Decrease Fatigue

Scientists isolated the neurotransmitter GABA from white mulberry leaves. It increased endurance in mice during exercise, as well as improved several biological indicators of fatigue (such as glycogen and hormone levels).


White mulberry leaves contain several antimicrobial flavonoids, alkaloids, and stilbenoids. Their extract also showed antimicrobial activity in mice (against Staphylococcus aureus, Pseudomonas aeruginosa, Candida albicans, Candida krusei, Candida tropicalis, and Aspergillus flavus). Kuwanon G from white mulberry root bark significantly inhibited the growth of bacteria that may cause cavities and gum disease (Streptococcus mutans, S. sobrinus, S. sanguis, and Porpyromonas gingivalis) in test tubes.

White Mulberry Helps Cancer

Below, we will discuss some preliminary research on white mulberry’s potential anticancer effects. It’s still in the animal and cell stage and further clinical studies have yet to determine if its extract may be useful in cancer therapies. Do not under any circumstances attempt to replace conventional cancer therapies with white mulberry or any other supplements. If you want to use it as a supportive measure, talk to your doctor to avoid any unexpected interactions.

White mulberry extract prevented rats given a cancer-causing chemical (NDEA) from developing liver cancer. A compound isolated from white mulberry fruits (cyanidin-3-glucoside) killed breast cancer cells in test tubes and reduced tumor growth in mice.

White mulberry bark extract stopped colorectal cancer cell growth and induced their death. It activated the production of a cell death protein (ATF3) while decreasing the levels of a protein required for cell growth and division (cyclin D1). Its compounds morning and kuwanon C and G were possibly responsible for these effects.

28g Raw White Mulberry Nutrition

  • Calories: 90
  • Protein: 3 grams
  • Fat: 0.5 grams
  • Carbs: 22 grams
  • Fiber: 4 grams
  • Vitamin C: 130% of the Daily Value (DV)
  • Iron: 20% of the DV
  • Calcium: 8% of the DV
  • Vitamin A: 2% of the DV

White Mulberry Side Effects

Side effects are common with higher doses and may include mild diarrhea, dizziness, constipation, and bloating. Allergies are uncommon but can occur. Because of its effect on blood glucose, white mulberry should be used with caution in people on diabetic medications, including insulin. The combined use may trigger a steep drop in blood sugar (hyperglycemia) characterized by shaking, dizziness, sweating, fatigue, lightheadedness, and fainting.

The same may apply to the use of white mulberry along with drugs used to treat high blood pressure. Such a combination may trigger hypotension; the rapid drop in blood pressure can cause fatigue, lightheadedness, clammy skin, blurry vision, nausea, and fainting.


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