Vitamin D side effects have a lot of many. But we ensure the main side effects for your health. This article discusses 6 possible side effects of obtaining vitamin D side effects.
Vitamin D is essential for good health. It plays several roles in keeping your body cells healthy and functioning properly. Most people do not get enough vitamin D, so supplements are common. However, it is also possible that even though it is rare for this vitamin to also reach its toxic levels in your body.
Vitamin D Side Effects for Health
Deficiency and toxicity
Vitamin D is involved in calcium intake, metabolism, and protection of bones, muscles, and heart. It occurs naturally in food and can be produced by your body when your skin is exposed to the sun.
However, in addition to fatty fish, there are few foods rich in vitamin D. Also, most people do not get enough sunlight to produce enough vitamin D.
Therefore, deficiency is very common. In fact, an estimated 1 billion people worldwide do not get enough of this vitamin. Supplements are very common, and both vitamin D2 and vitamin D3 can be taken in supplement form. Vitamin D3 is produced in response to sun exposure and is found in animal products, while vitamin D2 is derived from plants.
Vitamin D3 has been found to increase blood levels significantly higher than D2. Studies have shown that each 100 IU supplement of vitamin D3 you use per day will increase your vitamin D levels by 1 ng/ml (2.5 nmol / l), on average. However, taking high doses of vitamin D3 for a long time can lead to excess buildup in your body.
Vitamin D intoxication occurs when blood levels rise above 150 ng/ml (375 nmol/l). Because the vitamin is stored in body fat and is released into the bloodstream slowly, the toxic effects can last for several months after you stop taking supplements.
Importantly, toxins are rare and occur almost exclusively in people who take long-term, high-dose supplements without monitoring their blood levels.
It is also possible to inadvertently consume a lot of vitamin D by taking supplements that contain much higher amounts than those listed on the label. Conversely, you cannot achieve high blood pressure with food and exposure to the sun alone.
Below are six side effects of vitamin D
High blood pressure
Getting enough vitamin D in your blood can help boost your immune system and protect you from diseases like osteoporosis and cancer. However, there is no consensus on the right range for adequate levels.
Although a vitamin D level of 30 ng/ml (75 nmol/l) is generally considered insufficient, the Vitamin D Council recommends maintaining levels of 40-80 ng/ml (100-200 nmol/l) and says anything above 100/ml (250 nmol/l) can be dangerous.
While a growing number of people supplement with vitamin D, it is rare to find a person with high blood levels of this vitamin.
One recent study looked at data from more than 20,000 people over a ten-year period. It has been found that only 37 people have levels above 100 ng/ml (250 nmol/l). Only one person had true toxicity, at 364 ng/ml (899 nmol/l).
In one study, a woman had a level of 476 ng/ml (1,171 nmol/l) after taking a supplement that gave her 186,900 vitamin D3 per day for two months. This was 47 times the maximum safe safe limit of 4,000 IU per day.
The woman was admitted to the hospital after fatigue, forgetfulness, nausea, vomiting, bad speech, and other symptoms. Although only large doses can cause toxicity very quickly, even the strongest proponents of these supplements recommend a maximum limit of 10,000 IU per day.
High blood calcium levels
Vitamin D helps your body absorb calcium from your diet. In fact, this is one of its most important roles. However, if vitamin D intake is high, the calcium in the blood can reach levels that can cause unpleasant and potentially dangerous symptoms.
Symptoms of hypercalcemia, or high levels of calcium in the blood, include:
- digestive disorders, such as vomiting, nausea, and
- abdominal pain
- fatigue, dizziness, and confusion
- excessive thirst
- frequent urination
The normal range of blood calcium is 8.5-10.2 mg/dl (2.1-2.5 mmol/l). In another study, an elderly man suffering from dementia who received 50,000 D of vitamin D daily for six months was hospitalized several times with symptoms related to high calcium levels.
In one, two men took inaccurately prescribed vitamin D supplements, resulting in blood calcium levels of 13.2-15 mg/dl (3.3-3.7 mmol/l). Also, it took a year for their levels to normal after they stopped taking supplements.
Nausea, vomiting, and loss of appetite
Many of the side effects of too much vitamin D are related to excess calcium in the blood. These include nausea, vomiting, and poor diet. However, these symptoms do not occur in everyone with high calcium levels.
One study followed 10 people who had significantly increased calcium levels after taking high-dose vitamin D to correct the deficiency. Four of them suffered from nausea and vomiting, and three of them lost their appetite.
Similar responses to vitamin D megadoses have been reported in other studies. One woman experienced nausea and weight loss after taking a supplement that was found to contain 78 times more vitamin D than prescribed by the label.
Importantly, these symptoms occurred in response to very high doses of vitamin D3, which resulted in higher calcium levels than 12 mg/dl (3.0 mmol/l).
Abdominal pain, constipation, or diarrhea
Abdominal pain, constipation, and diarrhea are common digestive complaints that are often associated with food intolerance or irritable bowel syndrome. However, they can also be a sign of high calcium levels caused by the intoxication of vitamin D.
These symptoms may occur in those who receive high doses of vitamin D to correct the deficiency. As with other symptoms, the response appears to be somewhat differentiated even if the blood levels of vitamin D are similarly high.
In another study, a boy developed abdominal pain and constipation after taking inappropriate ingredients of vitamin D, while his brother suffered high blood pressure without any other symptoms.
In another case study, an 18-month-old baby who was given 50,000 IU vitamin D3 for three months experienced diarrhea, abdominal pain, and other symptoms. These symptoms are resolved after the child has stopped taking supplements.
Because vitamin D plays an important role in calcium absorption and bone metabolism, getting enough is important for maintaining strong bones. However, too much vitamin D can damage bone health.
Although many symptoms of excessive vitamin D are said to have high levels of calcium in the blood, some researchers suggest that megadoses could lead to low levels of vitamin K2 in the blood.
One of the most important functions of vitamin K2 is to store calcium in the bones and blood. It is believed that very high levels of vitamin D can reduce the activity of vitamin K2.
To prevent bone loss, avoid taking excessive amounts of vitamin D supplements and taking a vitamin K2 supplement. You can also eat foods rich in vitamin K2, such as milk and grass milk.
Vitamin D intake often leads to kidney damage. In another study, a man was hospitalized for kidney failure, high blood calcium levels, and other symptoms that occurred after receiving vitamin D injections given by his doctor.
Indeed, many studies have reported moderate to severe kidney damage in people who develop vitamin D toxicity.
In another study of 62 people who received high doses of vitamin D, each person experienced kidney failure – whether they had a healthy kidney or an existing kidney disease. Kidney failure is treated with oral or intravenous hydration and medication.
Is it better to take vitamin D every day or once a week?
Current guidelines say adults shouldn't take more than the equivalent of 100 micrograms a day. But vitamin D is a 'fat-soluble' vitamin, so your body can store it for months and you don't need it every day. That means you could equally safely take a supplement of 20 micrograms a day or 500 micrograms once a month.
What is a safe amount of vitamin D to take daily?
Mayo Clinic recommends that adults get at least the RDA of 600 IU. However, 1,000 to 2,000 IU per day of vitamin D from a supplement is generally safe, should help people achieve an adequate blood level of vitamin D, and may have additional health benefits.
What should you not take with vitamin D?
Steroid medications such as prednisone can interfere with vitamin D metabolism. If you take steroid drugs regularly, discuss vitamin D with your doctor. The weight loss drug orlistat brand names include Xenical and Alli -- may cut absorption of vitamin D.
Is it safe to take vitamin D 5000 daily?
Even if you follow a healthy diet, you may require supplements to achieve optimal blood levels. However, it's also possible to have too much of a good thing. Make sure to avoid excessive doses of vitamin D. Generally, 4,000 IU or less per day is considered safe, as long as your blood values are being monitored.
Is it safe to take 50000 IU of vitamin D weekly?
Vitamin D3 therapy (50,000-100,000 IU/week) was safe and effective when given for 12 months to reverse statin intolerance in patients with vitamin D deficiency. Serum vitamin D rarely exceeded 100 ng/mL, never reached toxic levels, and there were no significant changes in serum calcium or eGFR.