Pomelo Fruit Side Effects

Here are the key potential side effects of consuming pomelo fruit:

Drug Interactions

Pomelo contains compounds called furanocoumarins that can interfere with the metabolism of certain medications by inhibiting enzymes in the liver. This can lead to increased drug levels in the bloodstream, potentially causing adverse effects or reducing the efficacy of medications.

Pomelo may interact with drugs like cyclosporine, sildenafil, and tacrolimus. Consuming pomelo juice with sildenafil may reduce its bioavailability, while the bioavailability of cyclosporine and blood levels of tacrolimus may increase after pomelo consumption.

Allergic Reactions

Some individuals may experience allergic reactions to pomelo, particularly if they have existing allergies to citrus fruits. Symptoms may include itching, swelling, hives, or difficulty breathing.

Gastrointestinal Upset

Eating large amounts of pomelo or consuming it on an empty stomach may cause gastrointestinal discomfort, including bloating, gas, or diarrhea, due to its high fiber content.

Skin Irritation

Consistent and excessive contact with the oil of the outer pomelo peel can cause skin irritation or dermatitis.

To avoid potential side effects, it is important to consume pomelo in moderation and be aware of any potential interactions with medications or allergies. Consulting with a healthcare professional is recommended, especially if you have any underlying health conditions or are taking medications.